sparr | Reading

2026 Jan 6: Görkem Şen (Yaybahar on YT): Yaybahar III Nadiri

The description text:

The essence of gold was rare, he conquered with his virtue, offered his gifts and fell behind the sun...

Dedicated to the soul of my dear friend's father, Nadir Oğuz...

I am surmising that "Nadiri" means "Of Nadir". Yaybahar is the instrument, the artist is its inventor:

The name yaybahar (pronounced /jajba'har/) has Turkish origin. It is a composite of two words: yay means a "string" or a "coiled string" and bahar means the season "spring." According to Gorkem Sen, the name is derived from the idea of a new life or a new beginning. [1]

I assume this is the third one of its kind the artist has made.

Artist's website: https://www.gorkemsen.com/

sorcyress

LB asked a few days ago, because I never did elaborate about Kale Pudding in here during the actual summer. So here is a story from Pinewoods this past July!

***

The Kale Pudding was a Pinewoods adventure, and I'm surprised about the part where I didn't give details any time this year, except of course I didn't, I have been _so shit_ at updating Dreamwidth. Oh well.

The ~~short~~long version: At Pinewoods dance camp Scottish Sessions, we have a big auction to raise money for camp. Because we raise fucktons of $$ (like, basically always five figures, this year was a record in the ~27,000 range), the crew of Pinewoods are often willing to donate various goods and services that they don't really offer to other sessions which split their $s between camp and the parent orgs (or don't donate to camp at all). One of these services, for several years, has been "the head cook will let you choose what the dessert for the last night of camp is".

We've had creme brulee. We've had sticky toffee pudding. We've had cheesecake. It's chances for the kitchen crew to flex on the fact that food at Pinewoods is _way_ outside the league of "camp food" anywhere else. And in...let's say 2021 or so? In about 2021, when the bidding started, I made a bid just to get things going and loudly announced that I was bidding on "kale pudding" for dessert. No one knew what that would, but they recognized it for the thread it sounded like, and outbid me.

Continue the running joke for several years. Cue 2024, at which point Geoffrey, who had frequently outbid me in the past, comes up to me and says "I've got $300 for you this year, I think it would be funny if you won". And so did someone else. Oh-ho-ho, with shadowbackers, I have an actual chance! Bidding gets to just over a thousand dollars before Terry says "okay, raise your hand if you'll throw in $50 for NOT kale pudding". (he then wasted it on Pot de Creme, which is a delicious chocolate treat that I just do not like and also that the kitchen like, regularly makes at camp? So it's not like you couldn't get it at Pinewoods in general? DO SOMETHING INTERESTING WITH YOUR DESSERT CHOICE, THE CREME BRULEE YEAR THE KITCHEN CREW GOT TO BORROW BLOWTORCHES THAT WAS AWESOME!)

So now I've got a challenge, a target, and a goal. And a whole bunch of people also into The Joke. At LCFD weekend, right at the start of the summer, I warn Amanda the head cook. I'm serious. I'm going to campaign. "And part of my campaign is predicated on 'I trust Amanda to make something _good_' so, uh, good luck babe". ESCape rolls around, the session immediately before Scottish, and some friends do actual campaigning for Make The Scots Eat Kale Pudding fund¹. I don't just have shadow-backers anymore, I have straight up donation-matchers. Like, more than one of them.

So at Scottish Sessions, I go ahead and start collecting a list of people I think it would be funny to get money from. A big ol' list of collaborators, and also making it clear that anyone could bid shadow-wise, and not have anybody but me know that they were in. I will be the fall guy for this BUT ALSO if anyone can make Kale Pudding taste good it's Amanda. Believe in them, you know? Auction night rolls around. Me and Geoffrey make a plan --he'll be the face guy for the ESCape part of the fund, and bid against me to make the $$ go up if necessary. We're gonna spook people, then he's gonna hit me with the "well, ESCape wants to be on the winning team" and throw in his funds so we can crush the competition.

...except no one else wants to bid on the dessert. The joke has just about hit its limits, and I have successfully either convinced everyone that Amanda is really good at their job and it'll taste good, or have intimidated them into thinking they're not going to bother. So Geoffrey and I have a (brief) screaming match of "I bid 1000...for kale pudding" "oh yeah? Well I bid 1500....for kale pudding!!!" until we reach $2500 and agree to go in together and then we gave Pinewoods camp a $5000 donation² in exchange for making the Scots eat kale pudding for their last night dessert.

Which Amanda made as "pot de brassica", a sort of violently neon green creamy pud, served with lemon curd, tasted sharp and interesting and yes like kale and delicious. Most people enjoyed it, or at least found it "good enough". Very few people didn't like it, but honestly, I don't like pot de creme which everyone else finds The Shit, so it's all normal.

And I assured a great many people that last year was the last year of the joke anyways, so it's going to be very very funny if the new kitchen head [Amanda has retired after their triumph] offers this same auction item and I bid any amount. What, I just want some lemon meringue pie!

AND THAT IS THE TALE OF THE KALE PUDDING!

~Sor

1: "Why should you care what some people a week from now eat for dessert? First off, you shouldn't. Second off, because it would be funny. And third off, because the money goes to a good cause..."

2: It is important to note that Geoffrey works in SF with computers, and we had a _lot_ of shadowbackers and donors. I did not pay anywhere near this amount myself.

sorcyress

I can tell I've been too long away from home and my proper routine, because this morning I was dithering a little bit going "wait, what should I do during breakfast, I can't knit and eat at the same time so that's obviously not it".

Like babe. You know this one.

You pour a bowl of cereal, you pour on some milk, you eat your cereal and milk and read the comics. This has been your routine since like nineteen fucking ninety six. Forty percent of your partners weren't born when you started this.

Also it means I'm actually going to read the dreamwidth friends page in who knows how fucking long (two weeks, give or take) so it'll be nice to know what y'all have been up to. On the one hand, we should bring back the phrase "pants bankrupt", on the other hand, maybe a good new years resolution would be to just...not be pants bankrupt very often this year?

(like, it'll happen around Pinewoods of course, but let's try not to let it happen at other points because Dreamwidth really is The Good Place and I would like to keep it running well.)

~Sor
MOOP!

sorcyress

Today was a day of very many games! And playing them with various people. And that's basically it.

_____@

I got to see Veronicaaaaa and play games with her, which is the Best Ever. And I saw Cameron and MaccyTu and Jonny!!!!! and Tuesday and Mom and played games with all them as well! Busy day!

We played:

Pit: I did very well in general, but I always do.

Hot Streak: Several rounds, I tended to do poorly, but had a very good time because it's very stupid fun!

Agricola: I came in first! It was a hardfought, and I never quite got my engines working the way I wanted, but I did manage to frantically make a whole bunch of fences in the last possible moment.

Kingsburg: Came in solidly fourth, c'est la vie, but I did not get killed by the demons, so that's a good start!

Space Base: Came in _painfully_ last place, like, fourteen points below second last, and I ended the game with 4 (the game ends when someone crosses 40). But I had a nice time!

I think that's everything we played? I also did some rounds of knitting, and much chatting and bomping my head into my friends and occasionally eating things. Tomorrow, Tuesday and I ride a train for many many hours. I am planning to listen to music and do some knitting and maybe actually touch my day job? Grading and the like? Aaaaah!

I will have to pack up tomorrow morning, I expect. Hm. Maybe I need to actually start to get my sleep schedule back into wack, so that I can go to work on Monday. Sigh!

That's me. I hope your life is also nice and full of friends and stuff.

~Sor
MOOP!

siderea

Interesting:

2025 Dec 31: DwarkeshPatel YT fea. Sarah Paine: Human Rights Killed Communism - Sarah Paine:

Watch on YouTube

BTW, that's Sarah C. M. Paine, until very recently the William S. Sims University Professor of History and Grand Strategy and the Ernest J. King Professor of Maritime History, both, at the US Naval War College. She's an incredibly interesting speaker. Recommended.

(Dwarkesh Patel is this random dude who mistakenly thinks he's a podcaster and keeps trying to have other guests, but in actuality was put on Earth to bring Paine to the masses. He's got something like 14 hours of her up on his channel.)

sorcyress

I have eaten a lot of junk food today, which is good, and played some board games, which is good, and done some mindless phone games, which is less good, and napped for like 2-3 hours, which is...fine, honestly, and spent quality time with good people, which is marvelous.

I also obtained a small green dinosaur plushie at the grocery store. She basically leapt into my bag and informed me that her name is Canope (rhymes with "Penelope"). She also has informed me I need to knit her a hat, which would be easier if she wasn't a triceratops. I have attempted to bargain her to scarf, she countered with "booties" which will also be difficult as her legs are extremely cute and stubby. We'll see what happens. Anyways, her goofy ability to get in the way while I'm trying to do other things (she rode home from the store in my lap, which was fine until I had to park and then she was annoyed I moved her so she wasn't in the way) has earned her the surname Catlike.

I do not always instantly personify my stuffed animals so thoroughly, but it is fun to meet them and see what's going on.

Whenever I fall asleep without an alarm on, I sleep until eleven, which feels too late, but also the body wants what the body wants. I've never _really_ been in a space where I could fully free-run, which is an absolute shame, because it would be interesting to see what happens. Maybe someday I will have to take a week's vacation entirely and fully by myself so I can so something like that.

Earlier today I made a bunch of pancakes, which was quite satisfying. I was helping Cameron and Tuesday! It is fun to have an extended family I can cook with. Friends who will game with me and have a nice time and All That.

And I dunno, that's where I'm at. Tomorrow I hang with Veronica, and probably more games and junk food, and then Saturday, Tues and I get on a train and return to Massachusetts. (Sunday night there is BIDA, and I should figure out if Maia is staying over at my place or not, and how that will all work out, considering then it's time to return to my job, and oh yeah, we better get some lessons prepped at some point. Seems like a task for a future Kat.

I hope your 2026 is starting off well!

~Sor
MOOP!

sorcyress

Wednesday, December 31st, 2025!

(the one day of the year when I feel slightly weird about keeping my cron to 6am instead of midnight, but it's okay. Nevermind that it's technically already almost midnight-thirty. Congrats, we made it to '26!)

Anyways, I haven't been writing much here, and that's a shame. I'd like to change that for 2026 maybe? I think my official New Years Resolution is to update my dailies spreadsheet more often than I did this past year. (I should probably collect the data on how-many-days at some point).

2025 was bullshit nonsense on a global and USA level. It was a kinda weird year on a personal level. I coped with the fact that I'm now the age my shitty abusive boyfriend was, and that it's officially been half my life since I was last raped. I got rid of my uterus, and then was copied by my mother (except I skipped the cancer part). I started my ninth year of teaching at The Dream Job, with an adorable bright-shiny-new mentee teacher, and an endlessly-patient co-teacher.

I have the same number and arrangement of partners as I started the year with, which is pretty grand. I like it when my love life is stable! (there's one small change, but I'll make a bigger post about it sometime. It's a good thing.) I have the same roommate situation as I started the year with, which is DEFINITELY grand. I have the same job, which I'm still happy with.

Last year I was part of the bargaining team for some excellent and groundbreaking contract work. This year I'm a building rep and I'm holding my bosses feet to the fire wherever possible about actually enforcing the things we won.

A couple months ago I started a new hobby, and I think knitting is Very Good For Me. It's fun! It's a lot of counting! I get to touch things! It's hopefully eventually going to supplant some of the phone games instinct and replace it with something better?

I started the year with ADHD, and I still have ADHD. I finally _finally_ about a month ago set up the focus-mode on my phone, and now for two hours every day my phone becomes an inaccessible brick where I can't do anything distracting. Not coincidentally, it's set to start about half an hour after my work day ends, or about when I'd be getting home from bells. It's working surprisingly well! Let's hope it continues, so written so true.

Dancing is really fucking good. Having _my dance_ is so fulfilling and joyful and I'm real happy that I have established my dance pedagogy ethos: "Do Hard Things Badly". (sometimes I manage to apply this ethos to my knitting and other hobbies as well). We've had enough people to do _some_ kind of dancing, every time we've had class, although we've learned a lot of five-person dances along the way, at least two of which are marvelous and I've been bringing to the wider world as much as possible.

My own dancing hasn't been happening as much, but I'm trying to bring myself to do more of it. (It doesn't help that the yeeterus took me out of dancing for a couple months, and then it was the start of the school year and frantic). I need to run through my program dances for the night of Scottish Pinewoods I am MCing this year, and I need to sign up for ESCape (since they asked me to teach again and all, iirc).

I have friends and have sometimes been a little better about keeping in touch with them? At the very very end of last year, I got back in touch with Tho, and we email sometimes. Veronica and I have calls every other week or so. Tailsteak and I watch Taskmaster most Thursdays, except for the ones where one of us is super busy or the ones where we just spend two hours shooting the shit and chatting about our lives. My work bestie has bought a house and now somehow lives even closer to me. There are neighbors and friends I love and I'm happy to see and hang with them.

I sang in my first ever choir, my first time in my life doing formalized SATB. We did Vivaldi's Gloria, and it was the high school choir and orchestra combo, with a smattering of teachers enthusiastically invited to join. I'm a tenor! Austin and Phoebe came to see me, and then we walked around the student art show with our jaws on the floor because of how stunning and talented the kids at my school are.

I don't know. Probably other good things happened this year. Kale pudding! Some weddings! Thanksgiving with two families! Absolutely no peal attempts and I don't even think I tried any quarters!

(And as Vicki looks over and says "what are you typing anyways?" I am reminded that in 2025, I wrote my words on 365 days. I have a streak that is 1,227 days long. I have missed 0.15% of the days since November 25th, 2018. That's pretty fucking cool, honestly.)

I love you. I end a lot of posts with that phrase --I think I started the habit in 2020, when we were all re-adapting how we related to the world, and then I decided I liked it. It's true though, I love people and humanity and beings and the spark and interesting things inside us all. I love _you_.

Happy new year. As I've been telling people, may your 2026 be better than your 2025 was. I'm starting the year curled up on the floor next to some lovely people from different eras of my life, playing board games and happily bickering. It's _delightful_.

<3
~Sor
MOOP!

denise posting in

dw_maintenance

Привет and welcome to our new Russian friends from LiveJournal! We are happy to offer you a new home. We will not require identification for you to post or comment. We also do not cooperate with Russian government requests for any information about your account unless they go through a United States court first. (And it hasn't happened in 16 years!)

Importing your journal from ЖЖ may be slow. There are a lot of you, with many posts and comments, and we have to limit how fast we download your information from ЖЖ so they don't block us. Please be patient! We have been watching and fixing errors, and we will go back to doing that after the holiday is over.

I am very sorry that we can't translate the site into Russian or offer support in Russian. We are a much, much smaller company than LiveJournal is, and my high school Russian classes were a very long time ago :) But at least we aren't owned by Sberbank!

С Новым Годом, and welcome home!

EDIT: Большое спасибо всем за помощь друг другу в комментариях! Я ценю каждого, кто предоставляет нашим новым соседям информацию, понятную им без необходимости искать её в Google. :) И спасибо вам за терпение к моему русскому переводу с помощью Google Translate! Прошло уже много-много лет со школьных времен!

Thank you also to everyone who's been giving our new neighbors a warm welcome. I love you all ❤️

siderea

"...but it turns out, mining is fun."

2025 Dec 26: Engineer Everything (user Engineer.Everything-i5g) on YT: Shall I go still deeper? #engineering #Minecraft #tunnel #mining #constr...

Watch on YouTube

vvalkyri

Failing to manage to get to sleep last night involved a whole lot of mom life pivot point greatest hits. Everything from the beginning of her first hospitalization to how things went with a different strengths to maybe it would have been better if I hadn't even been there after she broke her arm.

Good times.

vvalkyri

I very much appreciate Marmota and Trowa Barton sending me pictures from Boston, and I've got some people I should send messages to.

It does look like it was a great party and I hope to reconnect with the post posts at some point and I had a pretty good day after all yesterday. It's not a bunch of time on the phone with a couple people and then
Tarek came here to pick me up and we first went swimming and then used the showers and then drove out there and got there part way through the lesson and if he hadn't kept disappearing I might have wanted to leave a lot earlier but I had some very good dances and met some cool people and got much more of an idea of bachata and even got a little Acro in. The instructor may try finding Acro.

Speaking of acro, it's 2:00 to 6:00 today and I was not planning on getting there anywhere near that early and I still have some goo in my hair that I need to wash out and I still need to actually eat anything...

Getting to sleep at 6:00 was not clever. And part of that was putting goo in my hair when I first got inside.

siderea

2025 Nov 14: Jonasquin on YT: "Bridge over Troubled Water but it's a Renaissance Madrigal | Feat. Tabea Bös":

Watch on YouTube

There's more where that came from:

• Let It Be (a Renaissance Madrigal) | Feat. Anna Petrtylová

• 'Enjoy The Silence' by Depeche Mode in the style of a madrigal by Carlo Gesualdo da Venosa (1566 - 1613).

• Bach Chorale "Last Christmas" "From the Last Christmas Oratorio, BWV (Bach Wham Verzeichnis) 1984"

• If Stayin' Alive Had Been Written in 16th Century "From the BG Manuscript, ca. 1570"

• One Night in Bangkok but it's a 16th century chanson "If Clément Janequin (ca. 1485 - 1558) was the songwriter for Murray Head..."

• If 'A Whole New World' (Aladdin) had been composed in 16th century "From The First Booke of Songs or Airs by Ala(ddi)n Menken"

vvalkyri

I'm not sure I've ever had quite so much fomo about a single night event in another city. I would not have been able to leave DC until yesterday and as it turns out I have maintenance at 9a Monday to handle the shower leak I had thought was my fridge. (Which tells you how much parquet is toasted.). So flying would have been a mess and the huge SWA sale the flights weren't until Jan 8.

But damn I wish there were something specific really competing back here this weekend.

(It's not that I can't fill the time with things I need to do and with people I haven't seen for a while. Need to check in as to whether I'm going to Jewish Museum for the GBLT Jews in the capital city exhibit today. Glen Echo is dark. I have an invite to a different sort of dance tonight as well. )

But it's folks I really like and I don't necessarily see on other visits to that city and there's a whole lot of people I would really like to see and they would all be in one place.

And it's too late to drive. And honestly I don't know how much I trust Ms Olds for a drive that far. It's not like I haven't done that drive in one day a number of times. She's probably okay? But it didn't even dawn on me that driving could conceivably be a thing, because I have had so little brain all month. I mean granted it also sounds like they just had snow. And yesterday was supposed to be freezing rain here.

There's a whole lot of reasons I'm not up there and I hate it.

sorcyress

On the plus side, it is 2359 on the 24th, and all of the Chrimbo stuff is upstairs and ready and everything. We did it! We couldn't stop Christmas from coming, it came!

Here's some stuff from today:

Woke up and did fairly leisurely breakfast, while chatting with Alys and Charlie and mom. We had time to play a game of Moonshine, which I lost spectacularly, and then it was Off To The Shops, for last minute christmas shopping and also groceries.

We started with a couple of Very Large presents for dad, which necessitated me forcing mom to take a photo of me so I could send it to Shaenon Garrity, as life imitated art. I sure was a replica of Tip from the first storyline of Skin Horse, minus the gender-inappropriate pink angora sweater. (I was instead wearing a very gender appropriate Maya Kern skirt with pumpkins on it)

The presents were so large that we went straight home to swap the car out for those and collect Jonny!!!!! who is going to be doing Chrimbo with us this year. I'm excited about it! It's been ages and ages since we've had a brother at Christmas, and Jonny!!!!! is better than most. (He's one of the drama department teens mom adopted when I was in high school, who moved back to Maryland and joined the Gay Man's Choir of Washington like a year before mom did. It's great that they've gotten to spend a lot more time together!). Then mom and Jonny!!!!! and I went out to get the groceries, which was extra charming because he and I basically entered into a mini-contest of who could be more helpful at any given moment.

Ah, oldest daughter syndrome. <3

We got home, where Charlie put away the groceries and did some preliminary reorganization of the pantry, which badly needs it (I believe he plans to do more on the 26th). Then we ordered some Thai food for dinner (Chinese would be more traditional, but my parents have not yet located a good Chinese place, to everyone's sadness) and taught Jonny!!!!! how to play Moonshine. I did much better, but Jonny!!!!! still clinched the win.

Somewhere along the way "the kids" (a phrase I use ambiguously --using it exclusively like this, I mean just the people younger than me, if I use it inclusively, it's also me and Jonny!!!!!) watched Once Upon a Mattress, which was fun to hear in the other room.

We all finished wrapping presents, and then dad called for the traditional reading of The Night Before Christmas to us over the phone --he's working at the hospital overnight tonight, meaning I haven't actually seen him since getting to MD. To be fair, I arrived at piss late last night (I think my train was delayed by almost 2.5 hours altogether, most of it at the front end...I got on around 1525 for a train that was supposed to depart at 1337.). So he was in bed already, and then left for work well before I got up. I'll see him tomorrow!

Alys read Charlie the last two chapters of The Woman Who Rides Like A Man, with mom and I happily eavesdropping and fucking around mindlessly a bit. We're all very excited listening to Charlie make predictions since he didn't know the Alanna books at all before Al started reading them to him! Then it was time for evening chores and putting away the dishes and stuff, and just before bed, Santa showed up to fill the stockings! I helped with that, and off we went.

To write words, remembered at the last minute, and now I am cozy and warm. Time to find them sugarplums, because apparently the morning sibling gossip time starts at 0630. I am obviously complaining about it and equally obviously, am probably just fine with it. We'll see how I feel tomorrow morn.

Goodnight and be well!

~Sor
MOOP!

siderea

2025 Dec 24: ScienceDaily [press release?]: "Scientists reverse Alzheimer’s in mice and restore memory":

By examining both human Alzheimer's brain tissue and multiple preclinical mouse models, the team identified a key biological failure at the center of the disease. They found that the brain's inability to maintain normal levels of a critical cellular energy molecule called NAD+ plays a major role in driving Alzheimer's. Importantly, maintaining proper NAD+ balance was shown to not only prevent the disease but also reverse it in experimental models.

WARNING WARNING WARNING: Yes, there are OTC supplements for tinkering with your NAD+, but they are apparently/allegedly CARCINOGENIC (cause CANCER) at typical doses. DO NOT run out and do something stupid. Tinkering with your whole-body cellular metabolism has some gnarly failure modes. From this article:

Why This Approach Differs From Supplements

Dr. Pieper cautioned against confusing this strategy with over the counter NAD+-precursors. He noted that such supplements have been shown in animal studies to raise NAD+ to dangerously high levels that promote cancer. The method used in this research relies instead on P7C3-A20, a pharmacologic agent that helps cells maintain healthy NAD+ balance during extreme stress, without pushing levels beyond their normal range.

Continuing from the article:

NAD+ levels naturally decline throughout the body, including the brain, as people age. When NAD+ drops too low, cells lose the ability to carry out essential processes needed for normal function and survival. The researchers discovered that this decline is far more severe in the brains of people with Alzheimer's. The same pattern was seen in mouse models of the disease.

[...]

Amyloid and tau abnormalities are among the earliest and most significant features of Alzheimer's. In both mouse models, these mutations led to widespread brain damage that closely mirrors the human disease. This included breakdown of the blood-brain barrier, damage to nerve fibers, chronic inflammation, reduced formation of new neurons in the hippocampus, weakened communication between brain cells, and extensive oxidative damage. The mice also developed severe memory and cognitive problems similar to those seen in people with Alzheimer's.

[...]

This approach built on the group's earlier work published in Proceeding of the National Academy of Sciences USA, which showed that restoring NAD+ balance led to both structural and functional recovery after severe, long-lasting traumatic brain injury. In the current study, the researchers used a well-characterized pharmacologic compound called P7C3-A20, developed in the Pieper laboratory, to restore NAD+ balance.

The results were striking. Preserving NAD+ balance protected mice from developing Alzheimer's, but even more surprising was what happened when treatment began after the disease was already advanced. In those cases, restoring NAD+ balance allowed the brain to repair the major pathological damage caused by the genetic mutations.

Both mouse models showed complete recovery of cognitive function. This recovery was also reflected in blood tests, which showed normalized levels of phosphorylated tau 217, a recently approved clinical biomarker used to diagnose Alzheimer's in people. These findings provided strong evidence of disease reversal and highlighted a potential biomarker for future human trials.

Note, potential conflict of interest: the head of the lab, Dr Pieper, above, has a serious commercial interest in this proving out:

The technology is currently being commercialized by Glengary Brain Health, a Cleveland-based company co-founded by Dr. Pieper.

The actual research article:

2025 Dec 22: Cell Reports Medicine [peer-reviewed scientific journal]: Pharmacologic reversal of advanced Alzheimer's disease in mice and identification of potential therapeutic nodes in human brain by Kalyani Chaubey et al. (+35 other authors!):

Abstract:

Alzheimer's disease (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD. In advanced disease amyloid-driven 5xFAD mice, treatment with P7C3-A20, which restores nicotinamide adenine dinucleotide (NAD+) homeostasis, reverses tau phosphorylation, blood-brain barrier deterioration, oxidative stress, DNA damage, and neuroinflammation and enhances hippocampal neurogenesis and synaptic plasticity, resulting in full cognitive recovery and reduction of plasma levels of the clinical AD biomarker p-tau217. P7C3-A20 also reverses advanced disease in tau-driven PS19 mice and protects human brain microvascular endothelial cells from oxidative stress. In humans and mice, pathology severity correlates with disruption of brain NAD+ homeostasis, and the brains of nondemented people with Alzheimer's neuropathology exhibit gene expression patterns suggestive of preserved NAD+ homeostasis. Forty-six proteins aberrantly expressed in advanced 5xFAD mouse brain and normalized by P7C3-A20 show similar alterations in human AD brain, revealing targets with potential for optimizing translation to patient care.

Full text here: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00608-1

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Clarence "Sparr" Risher

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Page generated Jan. 7th, 2026 08:25 pm

Clarence "Sparr" Risher

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Yaybahar III Nadiri [music]

The Tale of the (Kale)PuddingMaster

What is a "roo-teen"

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On the work of human rights work [pols, hist]

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Happy New Year! (white rabbit!)

Привет! LiveJournal imports may be slow

"I initially planned to build a small storm shelter..." [civ eng]

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Went well

Bridge over Troubled Water by Simon and Garfunkadelt [music]

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Merry Christmas: Scientists reverse Alzheimer's in mice [sci/bio/med]

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January 2026

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